KETAMINE FACT SHEET FUNDAMENTALS EXPLAINED

two.1 Critical Dosage and Administration Data Ketamine hydrochloride injection should be administered by or beneath the route of physicians experienced while in the administration of general anesthetics, routine maintenance of the patent airway, and oxygenation and air flow. Continually monitor important signs in patients receiving ketamine hydroch

Metabolism Ketamine is metabolized through N-dealkylation on the active metabolite norketamine mainly by CYP2B6 and CYP3A4 and to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation with the cyclohexone ring to sort hydroxynorketamine compounds by way of CYP-dependent pathways, which are conjugated with glucuronic acid and sub